Views: 21 Author: Site Editor Publish Time: 2024-06-18 Origin: Site
If you are in the pharmaceutical manufacturing industry, then you should consider buying this premium solid dosage granulation machine. This pharmaceutical granulation equipment will ensure there is no cross-contamination.
Solid oral dosage granulator combines mixing, granulation, and drying processes to ensure continuous and stable production, The granulation drying production line can highly increase the yield of finished products.
The vacuum conveying device and lifting turnover discharging system can greatly decrease labor intensity and avoid dust pollution. it means that the Granulator drying production line saves on the cost of labor.
Hywell machinery oral solid dosage equipment (wet granulation line system) adopts automatic PLC control with the graphical interface. This means that the operation and process parameters can be set automatically for history review and print.
The CIP system in the solid dosage form granulation line can fulfill well cleaning effect for the granulator and dryer. The ex-proof system, reliable interlock, and earthing ensure the safety of the people, equipment, and environment.
If you would like to buy a custom solid-dose pharmaceutical manufacturing line, Hywell will work hard to meet the process and specifications. We can customize the designs and sizes of granulation lines.
Would you like to buy this solid-dose manufacturing process line? then Send your inquiry on Hywell machinery right now. Hywell company is a reliable and reputable solid dosing granulation line manufacturer in China. Hywell Machinery Co., Ltd will support with Project Initial design — Project Initial confirm — Project detailed design — Project confirm — Select Equipment specification. To provide the advanced service for customers, and to insure all the machines are suitable for each production line of customers.
The Granulation line for pharmaceutical solid dosage forms Consists of the Following Sections:
Equipment introduction: The Granulation line for pharmaceutical solid dosage formssystem is composed of a high shear granulator, wet granulator, fluid bed dryer (granulator), pneumatic vacuum feeder, dry granulator, hopper mixer and other feeding and discharging systems and connecting components. During the granulation process, powder materials are put into the wet granulator. All processes are operated in a closed environment, each device is compatible and smooth, and the final product is mixed and then tableted.
1. GHL-15 mixing and granulator: first step to mix the different kinds dry powder, when the different powder mixed into uniform, and then to add the binder into GHL machine to made into the required damp material , final the cutting knife makes the wet material into graunles.
2. The wet granule will discharge into wet granulator (Conical Mill) from GHL-15 to get required size.
3. After wet mill, the wet granule will be discharge and sucked into FL-20 fluid bed dryer for drying by negative pressure of FL-20 exhaust fan.
4. After drying, HS-1 will suck the dried granules from FL-20 into the dry granulator (Conical Mill).
5. After dry mill, the dried granule will be discharge into HF-30 for blending
6. After blending and then materials will be send to tableting machine.
SN | Item | Unit | Model |
1. | Model | GHL-15 | |
2. | Tank volume | L | 10 |
3. | Load materials | kg/batch | 5-8 |
4. | Stir power | KW | 2.2kw |
5. | Stir speed | r.p.m | 30～960 inverter control |
6. | Chopper power | KW | 0.75 |
7. | Chopper speed | r.p.m | 50～2990 inverter control |
8. | Compressor air pressure | Mpa | 0.4-0.6 |
9. | Compressor consumption | M⊃3;/min | 0.1 |
10. | Materials temperature | ℃ | Normal temperature |
11. | Noise | db | ＜45db |
1. Hywell company produces a series of small high-speed mixers that can complete mixing in one go, with a good mixing effect and no cross-contamination. It meets the GMP requirements of the pharmaceutical industry and is suitable for trial production of new products and medium and small batch production in laboratories and scientific research and teaching units.
2. This type of equipment has a safety interlocking device, which is safe and reliable when used; the equipment adopts a horizontal machine structure with good overall rigidity, simple structure, and easy maintenance; the main components are installed inside the machine body, covered with a 304 stainless steel casing, and the parts that are in direct contact with the material are all made of 304 stainless steel; the granulation process is closed, equipped with an elbow stirring paddle, with a 15-degree angle with the bottom of the pot, and the material quickly generates a burst flow during mixing, and 2-5 cutting knife sets.
3. This type of equipment uses a dual frequency converter to adjust the speed of the stirring paddle and cutting knife, and automatically controls the operation of the machine with timing; electrical control, and touch screen operation. PLC touchscreen control and button control are two modes for users to choose.
High Shear Granulator
High Shear Granulator
High Shear Granulation
Name | Description | Mark |
Main machine system | ||
Base | Frame structure/stainless steel plate/motor/pneumatic control components | |
Raw material container | The material tank is designed with a positive cone. The material rolls up and down from bottom to top during mixing, and the material is mixed evenly. The inner wall is smooth and easy to clean/integrated interchangeable | |
| Organic glass cover/liquid port | Customized closing cover to prevent dust leakage during work |
| The gap between the large knife and the bottom of the material container is less than 1mm/large knife, and the small knife shaft has a mechanical air seal device, which prevents lubricating oil from leaking out and materials from leaking in. It is easy to disassemble and clean. | |
Liquid filling system (quick atomization and liquid filling is required) | Pressure atomizing spray gun pressure tank filling | Optional, standard is manual feeding liquid |
Discharging device | Pneumatic opening/quick opening disassembly for easy cleaning | |
Transmission system | Brand motor direct connection synchronous start. | |
Seal | Metal mechanical seal plus gas seal is used to ensure that no dirt leaks out of the shaft and no material enters the shaft seal and gets stuck. | |
Control system | ||
Cabinet | 304 operation box | |
Control and operation mode | PLC program control/touch screen operation | |
Electrical components | PLC human-machine interface/module/inverter | |
Pneumatic components | Yadek | |
SN | Name | Model | Brand | Mark |
Electrical components | ||||
1 | Master control PLC programmable controller | Siemens | ||
2 | Inverter | 2.2kw | China | |
3 | Inverter | 0.75kw | China | |
4 | Master control shared touch screen and supporting expansion modules | 10inch | Siemens | |
5 | Electrical components | 1unit | Siemens | |
6 | Pneumatic components | 1unit | Yadek | |
Other | ||||
7. | Mixing motor | 2.2kw | Wannan | |
8. | Cutting motor | 0.75kw | Wannan | |
SN | Product Components | Materials | Mark |
1. | Main unit cover | SS304 | δ=2.5 |
2. | Main unit frame | A3 | δ=10 |
3. | Main unit side cover | SS304 | δ=2 |
4. | Raw material container | SS304 | δ=6 |
5. | Stirring paddle/cutting knife | SS304 | δ=8 δ=3 |
6. | Operation cabinet | SS304 | δ=2 |
7. | Gasket | silicone rubber | Food grade |
8. | Motor | ||
Note: Inner surface mirror polishing ≤ 0.4μm, outer surface brushed polishing ≤ 0.8μm. | |||
Item | unit | Model and specification |
Production capacity | Kg/H | 5-50 |
Motor power | kw | 0.75 |
Speed | rpm | 180-1440 |
Control speed mode | -- | Frequency control speed regulation |
Screen aperture | mm | Φ1-8 |
2.1. Dry and wet granulation homogenization and granulation.
2.2. Crushing and granulation of agglomerated materials.
2.3. Wet material granulation.
2.4. Crushing of heat-sensitive materials.
3.1. Low heat and dust during operation.
3.2. The stator screen is made of stainless steel plate and is not easy to damage.
3.3. It can handle sticky, gummy, hot and wet materials.
Name | Materials | Model | country of origin |
Main body | SUS304 | δ=1.5mm | Hywell Machinery |
Hopper | SUS304 | δ=2mm | Hywell Machinery |
Pelletizing knife | SUS304 | δ=8 | Hywell Machinery |
Screen | SUS304 | Φ1-8 Specify any specification | Hywell Machinery |
Motor | 0.75kw | Wannan | |
Inverter | 0.75kw | China | |
Electrical components | Siemens |
SN | Item | Unit | Model | |
1 | Functional module | -- | Top spray | |
-- | Granulating pot (top spray) | |||
2 | Raw material container volume | L | 20 | |
Production capacity | G/Batch | 3-5 | ||
3 | Number of spray guns | Head | 1 | |
4 | Electric heating power | kw | 6 | |
5 | Compressed air | pressure | Mpa | 0.4-0.6 |
Consumption | M3/h | 0.3 | ||
6 | Fan power | Kw | 4 | |
7 | Fan air volume | Hz | 0～50 controllable | |
8 | Inlet air temperature | °C | Room temperature -100℃ controllable | |
9 | Material temperature | °C | Automatic display | |
10 | Spray flow rate | r/min | 0～100 adjustable | |
11 | Clean-up time | s | Settable | |
12 | Yield rate | % | ≥99% | |
13 | Product moisture | 5‰～5% related to humidity | ||
14 | Noise | dB | Fan isolation treatment less than 65 decibels | |
fluid bed dryer
fluid bed dryer
fluid bed dryer
The material is suspended in a fluidized state under the action of clean hot air flow (negative pressure). Its surface is in full contact with the hot air, and is evenly heated, achieving the best heat exchange state, thus having extremely high efficiency. With a suitable spray system and further structural improvements, the fluidized bed becomes a multi-purpose process equipment that combines drying, granulation, and granulation.
This machine is equipped with a "top spray" system and is mainly used for mixing, drying, and granulation operations in the pharmaceutical, food, chemical and other industries.
Put the powder material for granulation into the fluidized bed, and the cold air enters from the heating chamber at the rear of the main machine. After being heated to the required temperature of the inlet air by the primary, medium and heater, it enters the fluidized bed. The powder is fluidized in the bed, and the granulation binder is sent into the double-fluid atomizer by the infusion pump. After being atomized, it is sprayed onto the fluidized material. The powders bridge each other, aggregate into granules and grow. After the water evaporates, it is carried out of the machine by the exhaust air.
(1) Granulation is performed through powder, which improves fluidity and reduces dust flying.
(2) The heavy-weight granulation method is adopted, and both heavy-weight and light-weight granulation can be performed.
(3) The spraying, mixing, granulation and drying processes are carried out simultaneously, which greatly reduces the process.
(4) Special anti-static filter bags are used to prevent the occurrence of static electricity.
(5) Granulation is carried out in a sealed system without leakage and dust flying.
(6) The equipment can be operated manually or automatically.
(7) The granulation process parameters are stable and the repeatability is extremely high.
(8) The equipment has no dead corners, fast unloading, and is easy to rinse, which complies with GMP standards.
Name | Description |
Intake air treatment system | |
Primary and secondary efficiency filter | - Primary effect (100 mesh stainless steel screen) (G4). - Medium effect (non-woven cotton protective net/primary effect (F7). - Pressure difference detection, meter display. |
Electric heating tube | - 304 stainless steel electric heating tube. - Stainless steel cabinet, using Siemens temperature module analog control adjustment to ensure temperature control accuracy of ±3℃. |
Cabinet | - Junior and high efficiency filter: single layer, heater: special profile, double layer insulation. |
Air inlet pipe | - 90° air supply duct from the air inlet processor to the cylinder base. - The number of ducts is limited to the standard equipment layout provided in the layout diagram (Note: the above components and part of the air supply duct are installed in non-clean rooms). - The temperature sensor quick interface of the air supply duct near the cylinder base. |
Installation sequence | - Primary and medium efficiency filter-heater-high efficiency filter-material container |
Main machine system | |
Foundation | - Connected to the side supports, suspended design, easy to clean the equipment and the floor. - Equipped with a drain outlet with quick-open connection at the lowest point. - Air-tight airbag on the base. - Airbag seal between the base and the top ring |
Materials tank | - Top spray raw material container. - The pull rod for moving the container is equipped with two height-adjustable fixed gaskets to ensure the balanced insertion of the container. - Eccentric shafts are set on both sides of the container, which cooperate with the support and limit seat plate on the trolley to ensure the horizontality of the container. - A plexiglass window is set at the front and back of the container, sealed with a silicone pad. - The container is equipped with a product sampler. - The bottom of the container is equipped with a swirl airflow distribution plate and a stainless steel mesh. |
Automatic discharging device | - The cylinder controls the discharge valve. - It is used for closed automatic discharge, and the discharge port is lower than the screen to ensure clean discharge. - After the closed discharge device is completed, it can be completely disassembled and cleaned, without sanitary dead corners. |
Spray granulation drying chamber | - Suspended on the side support, can be rotated out horizontally. - Multiple vertically arranged spray gun mounting holes and hole covers, the hole covers adopt a chuck quick-release structure, easy to install and remove. After installation, the hole cover is flush with the inner wall of the cylinder. - Tempered glass window, sealed with silicone pad. - Set the negative pressure feed port and quick-release pneumatic valve with appropriate inclination angle to use the equipment's own negative pressure to feed and avoid material accumulation. |
Filter Chamber | - Bag-type anti-static cloth filter vibration dust removal, continuous fluidization state, continuous spray granulation, and drying. - Special structure of filter suspension frame with automatic guide and locking function. - Cylinder lifting system, convenient for lifting and installation of filter bag, dust removal system with guide rod device. - Automatic pneumatically operated open/closed damper. Downward end face seal, a good sealing effect, improves the powder cleaning efficiency of the filter. It can prevent non-clean air backflow from polluting the cylinder and clean area. - Organic glass window, sealed with silicone pad, used to observe the working condition of the product filter bag. - Temperature sensor quick interface on the exhaust short pipe. |
Observation light | - An observation window is set on the back of the spray granulation drying chamber (including adding a window), equipped with a lighting spotlight. |
Cylinder base and top ring airbag seal | - A silicone airbag is set between the cylinder base and the top ring, and the airbag is inflated and sealed. (Including adding a quick interface for compressed air on the base). |
Spray liquid system | |
Spray gun | - Single-head single-nozzle pressure-type sprinkler, three-stage atomization design, improved "gas-liquid-gas" mixing ratio, high-precision CNC machining, good atomization quality, no drop-like or linear liquid flow phenomenon. - All media enter the sprinkler from their respective pipelines in the coaxial gun body, and the gun body is equipped with a positioning pin and a locking nut. - A control device for manually adjusting the atomization air pressure through a pressure reducing valve. |
liquid supply pump | - High quality peristaltic pump head, dedicated stepless speed regulation drive, no external extension board required. |
Exhaust air system | |
Fan | - Centrifugal high-pressure fan with shock absorber, installed in the box. - The fan inlet and outlet are connected to the exhaust pipe and silencer through flexible joints to isolate the fan vibration. |
Exhaust duct | - The exhaust pipe from the fan to the filter chamber exhaust is installed in the non-purified room. The number of pipes is provided according to the equipment installation diagram. |
Fan automatically changes frequency to adjust air volume | Automatic air volume adjustment |
Control System | |
Strong and weak current cabinet | - The operating box is made of SUS304 and is placed in the operating room, meeting GMP requirements. - The operating box has display instruments and a touch screen operation interface. - The electrical box contains all necessary control electrical appliances and wiring, including PLC program controller, air switch, relay, contactor, inverter, etc. |
Control and operation mode | - PLC program control, Chinese and English interface, setting data, etc. - PLC settings for power on/off lock. - Temperature, atomizing air pressure, liquid supply pump speed, powder cleaning cycle and frequency (touch screen display and setting), fan frequency conversion. - Touch screen, instead of control buttons. Intuitive screen and multiple parameter display, flexible setting and adjustment. |
Process program storage | It can store 20 sets of mixing process programs with different recipes. |
System security access | The factory sets 3 levels of access passwords with different permissions to ensure system data security and data integrity. |
Record | Record the names, process procedures and operators of the 20 groups of drugs produced recently for traceability query; data can be exported to a USB flash drive. |
Fault alarm | Alarm for loss of normal production conditions, overload alarm. |
Pneumatic components | - Execution control element. |
The pneumatic vacuum feeder uses compressed air to generate high vacuum through a vacuum generator to transport materials. It does not require a mechanical vacuum pump and has the advantages of simple structure, small size, maintenance-free, low noise, easy control, elimination of material static electricity, and compliance with GMP requirements. The high vacuum generated by the vacuum generator eliminates the stratification of the transported materials and ensures the uniformity of the components of the mixed materials. It is the preferred equipment for automatic feeding of machines such as tablet presses, capsule filling machines, dry granulators, packaging machines, grinders, and vibrating screens.
When compressed air is supplied to the vacuum generator, the vacuum generator generates negative pressure to form a vacuum airflow, and the material is sucked into the suction nozzle to form a material airflow, which passes through the suction pipe to reach the hopper of the feeder. The filter completely separates the material from the air. When the material fills the hopper, the controller automatically cuts off the air source, the vacuum generator stops working, and the hopper door automatically opens, and the material falls into the hopper of the equipment. At the same time, the compressed air automatically cleans the filter through the pulse backflush valve. When the time is up or the material level sensor sends a feeding signal, the feeder is automatically started.
SN | Item | Parameter |
1 | Conveying capacity | 50-300kg/h |
2 | Binding volume | 1.1L |
3 | Working pressure | 0.4-0.6Mpa |
4 | Compressed air consumption | 180NL/min |
Name | Qty | Mark | |
Vacuum generator | 1 piece | China | |
304 stainless steel filter | 4 pieces | China | |
Vacuum hopper (SUS304) | 1 set | Hywell machinery | |
Compressed air backflush system | 1 set | 1unit | China |
Pneumatic parts | China | ||
Control System | Circuit board | 1 set | Hywell machinery |
Switching power supply | 1 piece | China | |
Solenoid valve | 1 piece | China | |
Suction hose (Φ25) Imported PU hose (food grade) | 3 meters | China | |
Stainless steel suction nozzle (Φ25) | 1 piece | Hywell machinery | |
Item | Unit | Model |
Production capacity | Kg/H | 5-50 |
Motor power | kw | 0.75 |
Speed | rpm | 180-1440 |
Control speed mode | -- | Frequency conversion control speed |
Screen aperture | mm | Φ1-8 |
2.1. Dry and wet granulation homogenization and granulation.
2.2. Crushing and granulation of agglomerated materials.
2.3. Wet material granulation.
2.4. Crushing of heat-sensitive materials.
3.1. Low heat and dust during operation.
3.2. The stator screen is made of stainless steel plate and is not easy to damage.
3.3. It can handle sticky, gummy, hot and wet materials.
Name | Materoals | Model | Mark |
Main body | SUS304 | δ=1.5mm | Hywell Machinery |
Hopper | SUS304 | δ=2mm | Hywell Machinery |
Pelletizing knife | SUS304 | δ=8 | Hywell Machinery |
Screen | SUS304 | Φ1-8 Specify any specification | Hywell Machinery |
Motor | 0.75kw | Wanan | |
Inverter | 0.75kw | China | |
Electrical components | Siemens |
SN | Item | Unit | Model |
1 | Model | -- | HF-30 |
2 | Hopper capacity | L | 30 |
3 | Maximum working load | Kg | 2-15 |
4 | Filling factor | 0.5-0.8 | |
5 | Working speed | r/min | 3-25/ Adjustable |
6 | Motor power | Kw | 0.55 |
HS series laboratory hopper mixer is a type of hopper mixer. It is one of the equipment to complete the small-scale mixing process of solid dosage medicine production. It is mainly used for mixing solid particles and powders, particles and particles, powders and powders in the pharmaceutical industry. It is also suitable for the production process of powder materials in the food, fine chemical industry and other industries. It has the advantages of good mixing effect and no cross contamination and dust pollution.
1. The hopper can be removed and sent to the cleaning room for cleaning or sterilization in the sterilization room.
2. The mixing hopper and exposed surface of this machine are made of high-quality austenitic stainless steel 304, with a smooth and flat surface and no concave structure, which complies with the GMP regulations for pharmaceutical production.
3. The inverter speed regulation ensures stable and reliable operation.
4. The transmission system consists of a reducer with a brake motor, with a simple transmission chain and reliable braking.
Function items | Description | Basic/Optional |
Feeding | ||
Manual feed | The operator opens the mixing hopper cover and manually adds materials | Basic |
Mixing | ||
Mixed speed control | Adjustable within (3～25) rpm range | Basic |
Time setting | Can be set arbitrarily within (0～60) min | Basic |
Rotation direction | Single direction rotation | Basic |
Stage setting | Set speed mixing → rotation positioning | Basic |
Discharging | ||
Gravity discharge | Place the material receiving container under the discharging butterfly valve and open the butterfly valve for gravity discharging. | Basic |
Process Automation | ||
Name | Model | Material | Original |
Main unit | δ=1.5mm | Inner channel steel/outer SS304 | Hywell |
Hopper | 30L | SS304 | Hywell |
Feed port | SS304 | Hywell | |
Discharge port | Stainless steel butterfly valve | Hywell | |
Electrical components | Touch button | Chint | |
Matching motor | 0.55kw | Wanan | |
Bottom of silo with wheels | ∅50 | Bracket 304/wheel polyurethane | China |
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